This study provides insights into the thoracic manifestations of connective tissue diseases (CTDs) using high-resolution computed tomography (HRCT). CTDs encompass a spectrum of autoimmune disorders that often affect the lungs and thoracic structures, leading to various pulmonary manifestations. Through a systematic review and analysis of HRCT findings, this research aims to identify common patterns and abnormalities observed in CTD patients, such as interstitial lung disease, pleural involvement, and pulmonary vascular abnormalities. Understanding these thoracic manifestations is critical for early detection, accurate diagnosis, and effective management of respiratory complications in CTD patients.

Connective tissue diseases, thoracic manifestations, high-resolution computed tomography

Bouros D, Wells AU, Nicholson AG, et al. Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome. Am J Respir Crit Care Med. 2002;165(12):1581-1586.

Watadani T, Sakai F, Johkoh T, et al. Interobserver variability in the CT assessment of honeycombing in the lungs. Radiology. 2013;266(3):936-944.

Ochs RL, Masi AT. Interstitial lung disease with systemic sclerosis and polymyositis-dermatomyositis. Rheum Dis Clin North Am. 1994;20(4):841-866.

Lynch DA, Godwin JD, Safrin S, et al. High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Am J Respir Crit Care Med. 2005;172(4):488-493.

Tashkin DP, Elashoff R, Clements PJ, et al. Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med. 2006;354(25):2655-2666. doi:10.1056/NEJMoa055120

Goldin JG, Lynch DA, Strollo DC, et al. High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung disease. Chest. 2008;134(2):358-367.

Wells AU, Cullinan P, Hansell DM, et al. Fibrosing alveolitis associated with systemic sclerosis has a better prognosis than lone cryptogenic fibrosing alveolitis. Am J Respir Crit Care Med. 1994;149(6):1583-1590.