The objective of the study is to assess the dynamics of inflammatory and organ indicators in patients with sepsis using specialized parenteral nutrition including amino acids. The analysis was conducted based on levels of inflammatory markers (C-reactive protein, fibrinogen, ESR), organ dysfunction (APACHE II and SOFA scores), and treatment effectiveness. Results indicate that the inclusion of specialized amino acids contributes to an earlier reduction in inflammation markers and severity of the condition.

The first reports of clinical cases of kidney injury in patients with COVID-19 were published by Chinese clinicians in the early days of the disease pandemic. Statistics confirm that with COVID-19, kidney injury was noted in an average of 0.6-7.6% of cases. We analyzed the features of the clinical manifestation of kidney injury in 62 patients who had had SARS-CoV-2. The distribution of patients was carried out on the basis of a prospective targeted open-label randomized study. We have found that in patients who have had SARS-CoV2, the pathological process in the kidneys mainly proceeds according to the acute inflammatory type, characterized by the predominance of diffuse endocapillary exudation. In patients with long-term consequences of kidney injury after SARS-CoV2, diffuse endocapillary proliferation becomes prevalent, which after coronavirus endotheliitis can inevitably lead to the development of chronic renal failure.