The first reports of clinical cases of kidney injury in patients with COVID-19 were published by Chinese clinicians in the early days of the disease pandemic. Statistics confirm that with COVID-19, kidney injury was noted in an average of 0.6-7.6% of cases. We analyzed the features of the clinical manifestation of kidney injury in 62 patients who had had SARS-CoV-2. The distribution of patients was carried out on the basis of a prospective targeted open-label randomized study. We have found that in patients who have had SARS-CoV2, the pathological process in the kidneys mainly proceeds according to the acute inflammatory type, characterized by the predominance of diffuse endocapillary exudation. In patients with long-term consequences of kidney injury after SARS-CoV2, diffuse endocapillary proliferation becomes prevalent, which after coronavirus endotheliitis can inevitably lead to the development of chronic renal failure.

kidney injury after SARS-CoV2, endotheliitis, chronic renal failure

Acute kidney injury associated with COVID-19: A retrospective cohort study / N.V. Kolhe, R.J. Fluck, N.M. Selby, et al. // PLoS Medicine. – 2020. – Vol. 17 - No10 – P. e1003406.

Acute kidney injury in China: a cross-sectional survey / L. Yang, G. Xing, L. Wang, et al. // Lancet. – 2015. – Vol. 386 - No10002 – P. 1465–1471.

Acute kidney injury in patients with SARS-CoV-2 infection / A. Joseph, L. Zafrani, A. Mabrouki, et al. // Annals of intensive care. – 2020. - Vol. 10 - No1 – P. 117.

AKI in hospitalized patients with and without COVID-19. A comparison study / M. Fisher, J. Neugarten, E. Bellin, et al. // Journal of the American Society of Nephrology: JASN. – 2020. – Vol. 31 - No9 – P. 2145–2157.

Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series / M.G. Argenziano, S.L. Bruce, C.L. Slater, et al. // BMJ (Clinical research ed.). – 2020. - Vol. 369 – P. m1996.

Clinical Characteristics and Outcomes of Community- and Hospital- Acquired Acute Kidney Injury with COVID-19 in a US Inner City Hospital System / J. Pelayo, K.B. Lo, R. Bhargav, et al. // Cardiorenal Medicine. - 2020. – Vol. 10 - No4 – P. 223-231.

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centre, retrospective, observational study / X. Yang, Y. Yu, J. Xu, et al. // The Lancet. Respiratory medicine. – 2020. – Vol. 8 - No5 – P. 475–481.

Community- and Hospital-Acquired Acute Kidney Injury in COVID-19: Different Phenotypes and Dismal Prognosis / A.J. Martínez-Rueda, R.D. Álvarez, R.A. Méndez-Pérez, et al. // Blood purification. – 2021. – Vol. 50 - No6 – P. 931-941.

COVID-19-related acute kidney injury; incidence, risk factors and outcomes in a large UK cohort / P.D. Jewell, K. Bramham, J. Galloway, et al. // BMC nephrology. – 2021. – Vol. 22 - No1 – P.359.

Epidemiology and Outcomes of Acute Kidney Injury in COVID-19 Patients with Acute Respiratory Distress Syndrome: A Multicenter Retrospective Study. / F. Wang, L. Ran, C. Qian, et al. // Blood Purif. 2021;50(4-5):499-505.

Incidence, outcomes, and risk factors of community-acquired and hospital-acquired acute kidney injury: a retrospective Cohort Study / C.N. Hsu, C.T. Lee, C.H. Su, et al. // Medicine. – 2016. – Vol. 95 - No19 – P. e3674.

Outcomes Among Patients Hospitalized With COVID-19 and Acute Kidney Injury / J.H. Ng, J.S. Hirsch, A. Hazzan, et al. // American journal of kidney diseases: the official journal of the National Kidney Foundation – 2021. - Vol. 77 - No2 – P. 204-215.e1.

Outcomes for patients with COVID-19 and acute kidney injury: A systematic review and meta-analysis / S.Y. Robbins-Juarez, L. Qian, K.L. King, et al. // Kidney International Reports. – 2020. – Vol. 5 - No8 – P. 1149–1160.

Risks of AKI and Major Adverse Clinical Outcomes in Patients with Severe Acute Respiratory Syndrome or Coronavirus Disease 2019 / J.Y. Teoh, T.C. Yip, G.C. Lui, et al. // Journal of the American Society of Nephrology : JASN. – 2021. – Vol. 32 - No4 – P. 961–971.

The prevalence of acute kidney injury in patients hospitalized with COVID-19 infection: A systematic review and meta- analysis / S.A. Silver, W. Beaubien- Souligny, P.S. Shah, et al. // Kidney Medicine. – 2021. – Vol. 3 - No1 – P. 83–98.e1.