Progress in chemotherapy for African trypanosomiasis, caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, is crucial for controlling this neglected tropical disease. This comprehensive overview examines the evolution of drug treatments, mechanisms of action, resistance patterns, and therapeutic efficacy in the context of African trypanosomiasis chemotherapy. Various classes of drugs, including suramin, pentamidine, melarsoprol, eflornithine, and newer agents like fexinidazole, are evaluated for their effectiveness and safety profiles. The review discusses the importance of combination therapies, pharmacokinetics, and pharmacodynamics in optimizing treatment outcomes and overcoming drug resistance. Additionally, emerging therapeutic strategies and ongoing research efforts aimed at developing novel antitrypanosomal agents are highlighted, offering insights into the future directions of chemotherapy for African trypanosomiasis.

African trypanosomiasis, Chemotherapy, Pharmacokinetics

Aiyedun, B. A., Williamson, J. and Amodu, A. A. The effect of Cordycepin on tsetse-borne Trypanosoma vivax infections. Acta tropica, 1973; 30: 216-2X

Brack, C. and Delain, E. Electron-microscopic mapping of AT-rich regions and of E. coli RNA polymerase-binding sites on the circular kinetoplast DNA of Trypanosoma cruzi. Journal of Cell Science, 1975; 17: 287-306.

Brack, C., Delain, E., Riou, G. and Festy, B. Molecular organization of the kinetoplast DNA of Trvnanosoma cruzi treated with Berenil, a DNA in&acting drug. Journal of Ultrastructure Research, 1972; 39: 568-579.

Buys, C.H.C.M., Elferink, M.G.L., Bouma, I.M.W., Gruber. M. and Nieuwenhuis. P. Proteolysis of formaldehyde-treated albumin in ‘Kupber cells and its inhibition by suramin. Journal of the Reticuloendothelial Society, 1973; 14: 209-223.

Dann, O., Walker. P. J., Kaddu. J. and Watts. J.M.A. ‘Preliminary observations on the chemotherapeutic activity of three new diamidines. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1971; 65: 266.

Davies, M., Lloyd, J. B. and Beck, F. The effect of Trypan Blue, suramin and aurothiomalate on the breakdown of 1251-labelled albumin within rat liver lysosomes. Biochemical Journal, 1971; 121: 21-26.

Delain. E. and Riou. G. Ultrastructure des alterations du DNA du kinetoplaste de Trypanosoma cruzi trait& par le bromure d’ethidium. Comptes Rendus hebdomaires des Seances de l’dcademie des Sciences. Paris, Serie D, 1969; 268: 1327-1330.

Delain, E., Brack, C., Riou, G. and Festy, B. Ultrastructural alterations of Trypanosoma cruzi kinetoplast induced by the interaction of a trypanocidal drug (hydroxystilbamidine) with the kinetoplast DNA. Journal of Ultrastructure Research, 1971; 37: 20 & 218.

Festy, B., Sturm, and Daune, M. Interaction between hydroxystilbamidine and DNA. I. Binding isotherms and thermodynamics of the association. Biochimica et biophysics Acta, 1975; 407; 24-42.

Fink, E. and Dann, O. The specific curative and prophylactic activity of diamidines against T. Rhode siense and T. congolense. In Les moyens de lute contre les trypanosomes et leurs vecteurs Actes du Colloque, pp. 297-300. Institut d’glevage et de Medecine Veterinaire des Pays Tropicaux. Paris: Office International des Epizooties, 1974.