Background: Inflammatory diseases represent a major global health burden, and the search for novel, effective, and safe anti-inflammatory agents from natural sources remains a critical area of research. Lablab purpureus, a plant traditionally used in folk medicine, is a promising candidate due to its reported pharmacological properties. This study aimed to investigate the anti-inflammatory potential of the methanolic extract of L. purpureus leaves.

Methods: The anti-inflammatory activity of the L. purpureus methanolic leaf extract was evaluated in Wistar albino rats using two established in vivo models: the carrageenan-induced paw edema model for acute inflammation and the formalin-induced paw edema model for chronic inflammation. Doses of 100 mg/kg and 200 mg/kg of the extract were administered orally to the experimental groups, while control groups received a standard anti-inflammatory drug (Indomethacin) or a vehicle. The anti-inflammatory effect was determined by measuring changes in paw volume at specific time intervals.

Results: The results demonstrated that the methanolic leaf extract of L. purpureus exhibited significant anti-inflammatory activity in a dose-dependent manner. In the carrageenan-induced model, the extract significantly reduced paw edema compared to the control group, with efficacy comparable to the standard drug. Similarly, in the formalin-induced model, the extract showed a marked reduction in paw swelling, indicating its potential to manage both acute and chronic inflammatory responses.

Conclusion: This study confirms the significant anti-inflammatory activity of Lablab purpureus leaf extract in Wistar albino rats. The findings suggest that the plant possesses therapeutic value and could serve as a potential source for developing new anti-inflammatory agents. Further research is warranted to isolate and characterize the specific bioactive compounds responsible for this observed activity.

Lablab purpureus, Anti-inflammatory, Phytotherapy

Prof Dr Ali Esmail Al-Snafi, The pharmacology and medical importance of Dolichos lablab (Lablab purpureus) - A review., IOSR Journal Of Pharmacy, (e)-ISSN: 22503013, (p)-ISSN: 2319-4219, Feb 2017; 7(2): 22-30.

Olfert E. D, Cross B. M, McWilliam A. A. Canadian Council of Animal Care guide to the care and use of experimental animals. (2nd edition), 1993; 1.

M. S. DivyaSree, An overview on anti-inflammatory activity of Indian herbal plants International Journal of Research in Pharmaceutical and Nano Sciences, 2015; 4(1): 1-9.

Shailly Gupta., leaves extract of Murrayakoenigii Linn for anti-inflammatory activity and analgesic activity in animal models., J Adv Pharm Technol Res., 2010 Jan-Mar; 1(1): 687.

A.Tamilsalvan, Anti inflamatory activity of pupalialappacea L. Juss., int.j.ofAllied.Med.Sci. And Clin. Research, 2014; 2(2): 97-101.

Amin Chowdhury et al., Human Red Blood Cell Membrane Stability Testing For The Estimation Of Anti-inflammatory Activity Of Methanolic Extract of MillettiaPachycarpa Benth Leaves., IJPSR, 2013; 4(12): 4587-4590., E-ISSN: 09758232; P-ISSN: 2320-5148.

Siddiqui AA and Ali M; Practical Pharmaceutical Chemistry; 1st ed.; CBS Publishers and Distributors, New Delhi, 1997; 126-131.

Evans WC; Trease and Evans pharmacognosy; London: WB Saunders, 2002.

Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non inflammatory pain. Pain, 1987; 30: 103–114.