Articles
| Open Access |
https://doi.org/10.55640/ijmm-03-10-06
THE IMPORTANCE OF KLOTHO PROTEIN IN THE DIAGNOSIS OF CHRONIC KIDNEY DISEASE
Abstract
Chronic kidney disease (CKD) is an intrinsically systemic infection that alludes to a long-term misfortune of kidney work. The movement of CKD has repercussions for other organs, driving to numerous sorts of extrarenal complications. Seriously ponders are presently being attempted to uncover the hazard components and pathophysiological component of this malady. Amid the past 20 a long time, expanding prove from clinical and fundamental ponders has shown that klotho, which was at first known as an anti-aging quality and is primarily communicated within the kidney, is altogether connected with the improvement and movement of CKD and its complications. Here, we talk about in detail the part and pathophysiological suggestions of klotho in particle clutters, the aggravation reaction, vascular calcification, mineral bone clutters, and renal fibrosis in CKD. Based on the pathogenic component of klotho insufficiency and klotho decrease in pee early in CKD organize 2 and indeed prior in CKD stage 1, it isn't troublesome to get it that solvent klotho can serve as an early and delicate marker of CKD. Besides, the anticipation of klotho decay by a few components can weaken renal wounds, impede CKD movement, enhance extrarenal complications, and make strides renal work. In this audit, we center on the capacities and pathophysiological suggestions of klotho in CKD and its extrarenal complications as well as its potential applications as a demonstrative and/or prognostic biomarker for CKD and as a novel treatment methodology to progress and diminish the burden of comorbidity in CKD.
Keywords
Chronic kidney disease, klotho protein, pathogenic mechanism
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