Articles | Open Access |

SERUM COPPER AND CERULOPLASMIN LEVELS IN EGYPTIAN AUTISTIC CHILDREN: INSIGHTS INTO NEURODEVELOPMENTAL DISORDER PATHOGENESIS

Youssef Abdelaal , Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Abstract

This study investigates serum copper and ceruloplasmin levels in Egyptian autistic children, aiming to elucidate potential associations between these biomarkers and autism spectrum disorder (ASD). A comparative analysis was conducted, involving serum samples collected from autistic children and age-matched neurotypical controls. Serum copper and ceruloplasmin levels were measured using standardized laboratory techniques. The findings reveal significant differences in serum copper and ceruloplasmin levels between autistic children and neurotypical controls, suggesting potential dysregulation of copper metabolism in ASD. Further exploration of these biomarkers may offer insights into the pathophysiology of autism and inform the development of targeted interventions and diagnostic strategies.

Keywords

Serum copper, ceruloplasmin, autism spectrum disorder

References

Makkonen, Ril Konen, Kokki, Airaksinen, Kuikka. Serotonin and dopamine transporter binding in children with Autism determined by SPECT. Dev Med Child Neurol 2008;50(8):593–7.

Ur-Adams Janet, Keen. Copper, oxidative stress and human health. Mol Aspects Med 2005;26(4–5):268–98.

Hellman, Gitlin. Ceruloplasmin metabolism and function. Annu Rev Nutr 2002;22:439–58.

Chauhan, Chauhan. Oxidative stress in autism. Pathophysiology 2006;13 (3):171–81.

Youngstrom, Glutiing, Watkins. Stanford-Binet International Scale 4th edition: evaluating the empirical bases for interpretations. In: Reynolds CR, Kamphaus RW, editor. 2003, Handbook of psychological and educational assessment: Intelligence, aptitude, and achievement (2nd ed.), pp. 217–242.

Schopler, Reichler, De Vellis, Daly. Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). J Autism Dev Disord 1980;10:91–103.

Sokol, O’Connor. Copper metabolism and copper storage disorders. In: Suchy RJ, Sokol WF, Balistreri, editors. Liver disease in children. Cambridge University Press; 2007. p. 628.

El-Baz, Elhossiny, Elsayed, Gaber. Hair mercury measurements in Egyptian autistic children. Egypt J Med Human Genetics 2010;11:135–41.

Christensen, Baio, Bilder, Charles, Constantino. Prevalence and characteristics of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, 2012. MMWR Surveill Summ 2016;65(3):1–23.

Al-Farsi, Al-Sharbati, Al-Farsi, Al-Shafaee, Brooks, Waly. Brief report: Prevalence of autistic spectrum disorders in the Sultanate of Oman. J Autism Dev Dis 2011;41(6):821–5.

Article Statistics

Downloads

Download data is not yet available.

Copyright License

Download Citations

How to Cite

SERUM COPPER AND CERULOPLASMIN LEVELS IN EGYPTIAN AUTISTIC CHILDREN: INSIGHTS INTO NEURODEVELOPMENTAL DISORDER PATHOGENESIS. (2024). International Journal of Modern Medicine, 3(03), 01-06. http://www.intjmm.com/index.php/ijmm/article/view/18