Urinary tract infections (UTIs) caused by multidrug-resistant bacteria pose significant challenges in clinical management and public health. This study investigates the efficacy of a synergistic approach involving medicinal plant extracts and an antibiotic cocktail in combating multidrug-resistant bacteria associated with UTIs. A comprehensive review of literature and experimental studies elucidates the mechanisms of action and therapeutic potential of medicinal plant extracts and antibiotic combinations. The abstract highlights the promising outcomes and potential implications of this synergistic approach for mitigating the growing threat of multidrug resistance in UTI treatment.