Medication-related problems (MRPs), including adverse drug reactions, inappropriate prescribing, and drug interactions, constitute a significant burden on healthcare systems globally, impacting patient safety, clinical outcomes, and healthcare costs. The complexity of modern pharmacotherapy, particularly in patients with polypharmacy and comorbidities, necessitates specialized expertise in medication management. Clinical Pharmacology Consultation (CPC) provides in-depth pharmacological assessment and evidence-based recommendations to optimize drug therapy. This article presents a single-center retrospective audit evaluating the impact and utility of CPCs in improving patient care. We analyzed the types of medication-related issues addressed, the recommendations provided by clinical pharmacologists, and their acceptance rates and documented effects on patient management. Our findings demonstrate that CPCs play a crucial role in identifying and resolving complex MRPs, leading to improved medication safety, enhanced therapeutic efficacy, and better overall patient care. These results underscore the significant value of integrating clinical pharmacology expertise into routine clinical practice, especially for challenging medication-related scenarios.