Articles
| Open Access |
https://doi.org/10.55640/ijmm-03-11-04
FEATURES OF MANIFESTATION OF NONALCOHOLIC STEATOHEPATITIS IN OBESE PATIENTS AFTER LAPAROSCOPIC SLEEVE GASTRECTOMY
Abstract
The state of energy starvation is the main phenomenon of the early postoperative period of bariatric surgery. All organs and systems of the body undergo such changes. Under normal physiological conditions, with the development of energy hunger, there is an excitation of metabolic centres in the hypothalamic-pituitary system of the brain. Transmitted impulses from chemoreceptor cells increase lipolysis, which ultimately leads to the mobilisation of large amounts of fatty acids from the fat depot to the liver. Excessively high concentrations of ketone bodies due to rapid weight loss are accompanied by the development of ketonemia, the severity of which depends not only on the compensatory capabilities of the body but also on the condition of the liver. Ketonemia is one of the common side effects reported by patients after bariatric surgery. Despite this, the evidence for the incidence of ketonemia after various bariatric surgeries and the mechanism of the development of this phenomenon is very limited. In this regard, this scientific article is devoted to the features of the manifestation of ketonemic syndrome in obese patients after the most popular type of bariatric surgery - laparoscopic longitudinal resection of the stomach.
Keywords
Obesity, bariatric surgery, longitudinal resection of the stomach
References
Bariatric surgery worldwide 2013. / L. Angrisani, A. Santonicola, P. Iovino, et al. // Obes. Surg.2015;25(10):1822-32.
Bariatric surgery: a systematic review and meta-analysis. / H. Buchwald, Y. Avidor, E. Braunwald, et al. // JAMA. 2024;2(4):1724–1737.
Laferrere B, Teixeira J, McGinty J, Tran H, Egger JR, Colarusso A, Kovak B, Bava B, Cauchy N, Lee H, Yapp K, Olivan B. Effect of weight loss with gastric bypass surgery compared to a hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2008; 93(7):2479–2485.
Bays HE, Jones PH, Jacobson TA, Cohen DE, Orringer CE, Kothari S, Azagury DE, Morton J, Nguyen NT, Westman EC, Horn DB, Scinta W, Primack C. Lipids and bariatric procedure’s part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: EXECUTIVE SUMMARY. Journal of Clinical Lipidology. 2016;10(1):15–32.
Taste changes after bariatric surgery: a Systematic Review. / K. Ahmed, N. Penney, A. Darzi, et al. // Obes. Surg.2018;28(10):3321–32.
Graham L., Murty G., Bowrey D.J. Taste, smell and appetite change after Roux-en-Y gastric bypass surgery. Obes Surg.2014;24(9):1463–8.
Tichansky D.S., Boughter J.D. Jr., Madan A.K. Taste change after laparoscopic Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding. // Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery.2006;2(4):440–4.
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. / E. Fabbrini, B.S. Mohammed, F. Magkos, et al. // Gastroenterology.2008;134:424-431.
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. / E. Fabbrini, B.S. Mohammed, F. Magkos, et al. // Proc. Natl. Acad. Sci. USA.2009;106:15430-15435.
Gene expression of leptin, resistin, and adiponectin in the white adipose tissue of obese patients with non-alcoholic fatty liver disease and insulin resistance. / A. Baranova, S.J. Gowder, K. Schlauch, et al. // Obes. Surg.2006;16:1118-1125.
Overproduction of large VLDL particles is driven by increased liver fat content in men. / M. Adiels, M. Taskinen, C. Packard, et al. // Diabetologia.2006;49:755-765.
Pioglitazone in the treatment of NASH: the role of adiponectin. / A. Gastaldelli, S. Harrison, R. Belfort-Aguiar, et al. // Aliment. Pharmacol. Ther.2010;32:769-775.
Targher G., Day C.P., Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. // N. Engl. J. Med.2010;363:1341-1350.
High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. / B. Vozarova, N. Stefan, R.S. Lindsay, et al. // Diabetes.2002;51:1889-1895.